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5.4pt; mso-para-margin:0in; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman",serif; mso-bidi-language:AR-SA;} </style> <![endif]--><!--[if gte mso 9]><xml> <o:shapedefaults v:ext="edit" spidmax="1026"/> </xml><![endif]--><!--[if gte mso 9]><xml> <o:shapelayout v:ext="edit"> <o:idmap v:ext="edit" data="1"/> </o:shapelayout></xml><![endif]--> </head> <body lang=EN-US link=blue vlink="#954F72" style='tab-interval:.5in;word-wrap: break-word'> <div class=WordSection1> <h3 style='margin:0in;text-align:justify;mso-line-height-alt:12.0pt'><span style='font-size:16.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family: "Times New Roman";color:navy'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span><span style='font-size:20.0pt;mso-fareast-font-family:"Times New Roman"'><o:p></o:p></span></h3> <table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=1047 style='width:785.0pt;border-collapse:collapse;mso-yfti-tbllook:1184; mso-padding-alt:0in 0in 0in 0in'> <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes;mso-row-margin-right:234.2pt'> <td width=468 colspan=4 valign=top style='width:350.9pt;border:none; border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='mso-line-height-alt:12.0pt'><b><span style='font-size:16.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family: "Times New Roman";color:navy'>DAHLIA WEISS</span></b><span style='font-size: 16.0pt;font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman"; color:navy'><br> </span><span style='font-size:11.0pt;font-family:"Times New Roman",serif; color:navy'>334 N Claremont Street<o:p></o:p></span></p> <p class=MsoNormal style='margin-left:.3pt;line-height:12.0pt'><span style='color:navy'>San Mateo, CA 94401 USA<o:p></o:p></span></p> <p class=MsoNormal style='margin-left:.3pt;line-height:12.0pt'><span class=MsoHyperlink><span style='text-decoration:none;text-underline:none'><o:p>&nbsp;</o:p></span></span></p> </td> <td width=267 colspan=4 valign=top style='width:199.9pt;border:none; border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='margin-left:.3pt;line-height:12.0pt'><span class=MsoHyperlink><span style='font-size:11.0pt;font-family:"Calibri Light",sans-serif; mso-ascii-theme-font:major-latin;mso-hansi-theme-font:major-latin;mso-bidi-theme-font: major-latin;text-decoration:none;text-underline:none'>dahlia.weiss at gmail.com<o:p></o:p></span></span></p> <p class=MsoNormal style='margin-left:.3pt;line-height:12.0pt'><a href="http://www.rationaldrugdesign.org"><span style='font-size:11.0pt; font-family:"Calibri Light",sans-serif;mso-ascii-theme-font:major-latin; mso-hansi-theme-font:major-latin;mso-bidi-theme-font:major-latin'>http://www.rationaldrugdesign.org</span></a><span class=MsoHyperlink><span style='font-size:11.0pt;font-family:"Calibri Light",sans-serif; mso-ascii-theme-font:major-latin;mso-hansi-theme-font:major-latin;mso-bidi-theme-font: major-latin'><o:p></o:p></span></span></p> <h3 style='margin:0in;mso-line-height-alt:12.0pt'><a href="https://www.linkedin.com/in/dahliaweiss/"><span style='font-size:11.0pt; font-family:"Calibri Light",sans-serif;mso-ascii-theme-font:major-latin; mso-hansi-theme-font:major-latin;mso-bidi-theme-font:major-latin;font-weight: normal;mso-bidi-font-weight:bold'>https://www.linkedin.com/in/dahliaweiss/</span></a><span class=MsoHyperlink><span style='font-size:10.0pt;font-family:"Calibri Light",sans-serif; mso-ascii-theme-font:major-latin;mso-hansi-theme-font:major-latin;mso-bidi-theme-font: major-latin;font-weight:normal;mso-bidi-font-weight:bold'>&nbsp;</span></span><span style='font-size:16.0pt;mso-fareast-font-family:"Times New Roman";color:navy; font-weight:normal;mso-bidi-font-weight:bold'><o:p></o:p></span></h3> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:1;mso-row-margin-right:234.2pt'> <td width=418 colspan=3 valign=top style='width:313.3pt;border:none; border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><b><span style='color:navy; text-transform:uppercase'>CURRENT Position</span></b></p> </td> <td width=317 colspan=5 valign=top style='width:237.5pt;border:none; border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'>&nbsp;</p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:2;mso-row-margin-right:233.55pt'> <td width=562 colspan=5 valign=top style='width:421.5pt;border:none; border-bottom:solid windowtext 1.0pt;mso-border-top-alt:solid windowtext 1.0pt; padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>Director, Computational Chemistry<o:p></o:p></span></p> <p class=MsoNormal style='line-height:12.0pt'><b><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>Septerna</span></b><span style='font-size:10.0pt;font-family:"Times New Roman",serif;color:navy'>, South San Francisco, CA<span style='mso-spacerun:yes'>     </span><o:p></o:p></span></p> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'><span style='mso-spacerun:yes'>                                                                                                     </span><o:p></o:p></span></p> </td> <td width=17 colspan=2 valign=top style='width:12.85pt;border:none; border-bottom:solid windowtext 1.0pt;mso-border-top-alt:solid windowtext 1.0pt; padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'><o:p>&nbsp;</o:p></span></p> </td> <td width=156 colspan=2 valign=top style='width:117.1pt;border:none; border-bottom:solid windowtext 1.0pt;mso-border-top-alt:solid windowtext 1.0pt; padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>2024-<o:p></o:p></span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=311 colspan=2><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:3;mso-row-margin-right:234.2pt'> <td width=191 valign=top style='width:143.2pt;border:none;border-bottom:solid windowtext 1.0pt; mso-border-top-alt:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><b><span style='color:navy; text-transform:uppercase'>Education</span></b></p> </td> <td width=387 colspan=5 valign=top style='width:290.2pt;border:none; border-bottom:solid windowtext 1.0pt;mso-border-top-alt:solid windowtext 1.0pt; padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>&nbsp;</span></p> </td> <td width=157 colspan=2 valign=top style='width:117.4pt;border:none; border-bottom:solid windowtext 1.0pt;mso-border-top-alt:solid windowtext 1.0pt; padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>&nbsp;</span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:4;mso-row-margin-right:234.2pt'> <td width=191 valign=top style='width:143.2pt;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='margin-top:6.0pt;line-height:12.0pt'><span style='font-size:10.0pt;font-family:"Times New Roman",serif;color:navy'>Ph.D.</span></p> </td> <td width=387 colspan=5 valign=top style='width:290.2pt;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='margin-top:6.0pt;line-height:12.0pt'><span style='font-size:10.0pt;font-family:"Times New Roman",serif;color:navy'>Structural Biology / Chemistry</span></p> </td> <td width=157 colspan=2 valign=top style='width:117.4pt;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='margin-top:6.0pt;line-height:12.0pt'><span style='font-size:10.0pt;font-family:"Times New Roman",serif;color:navy'>2009</span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:5;mso-row-margin-right:234.2pt'> <td width=578 colspan=6 valign=top style='width:433.4pt;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>Department of Chemistry, Stanford University, USA</span></p> </td> <td width=157 colspan=2 valign=top style='width:117.4pt;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'>&nbsp;</p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:6;mso-row-margin-right:234.2pt'> <td width=734 colspan=8 valign=top style='width:7.65in;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:black'>Advisor: Professor Michael Levitt, Computational Structural Biology </span></p> <p class=MsoNormal style='line-height:12.0pt'>&nbsp;</p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:7;mso-row-margin-right:234.2pt'> <td width=191 valign=top style='width:143.2pt;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span lang=FR style='font-size: 10.0pt;font-family:"Times New Roman",serif;color:navy;mso-ansi-language:FR'>Joint B.S. <i>Magna cum laude</i></span></p> </td> <td width=387 colspan=5 valign=top style='width:290.2pt;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>Chemistry and Biology</span></p> </td> <td width=157 colspan=2 valign=top style='width:117.4pt;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>2001</span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:8;mso-row-margin-right:234.2pt'> <td width=734 colspan=8 valign=top style='width:7.65in;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>Department of Chemistry and Department of Biology, Tel Aviv University, Israel</span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:9;mso-row-margin-right:234.2pt'> <td width=734 colspan=8 valign=top style='width:7.65in;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>&nbsp;</span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:10;mso-row-margin-right:234.2pt'> <td width=734 colspan=8 valign=top style='width:7.65in;border-top:solid windowtext 1.0pt; border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none; padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><b><span style='color:navy; text-transform:uppercase'>Publications AND PATENTS</span></b></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:11;mso-row-margin-right:234.2pt'> <td width=734 colspan=8 valign=top style='width:7.65in;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri; color:black'><span style='mso-list:Ignore'>1.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><![endif]><span dir=LTR></span><span style='color:black'>WO2021168197 Bifunctional degraders of interleukin-1 receptor-associated kinases and therapeutic use thereof (2021)<o:p></o:p></span></p> <p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri; color:black'><span style='mso-list:Ignore'>2.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><![endif]><span dir=LTR></span><span style='color:black'>WO2020081450 Bifunctional compounds for degrading btk via ubiquitin proteosome pathway (2020)<o:p></o:p></span></p> <p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri; color:black'><span style='mso-list:Ignore'>3.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><![endif]><span dir=LTR></span><span style='color:black'>WO2021021761 Urea, amide, and substituted heteroaryl compounds for cbl-b inhibition (2021)<o:p></o:p></span></p> <p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri; color:black'><span style='mso-list:Ignore'>4.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><![endif]><span dir=LTR></span><span style='color:black'>WO2020210508 3-substituted piperidine compounds for cbl-b inhibition, and use of a cbl-b inhibitor in combination with a cancer vaccine and/or oncolytic virus (2020)<o:p></o:p></span></p> <p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri; color:black'><span style='mso-list:Ignore'>5.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><![endif]><span dir=LTR></span><span style='color:black'>WO2020236654 Cyano cyclobutyl compounds for cbl-b inhibition and uses thereof (2020)<o:p></o:p></span></p> <p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri; color:black'><span style='mso-list:Ignore'>6.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><![endif]><span dir=LTR></span><span style='color:black'>WO2020264398 Substituted benzyl-triazole compounds for cbl-b inhibition, and further uses thereof (2020)<o:p></o:p></span></p> <p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri'><span style='mso-list:Ignore'>7.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><![endif]><span dir=LTR></span><b>DR Weiss</b>, JL Baylon, ED Evans, A Paiva, G Everlof, J Cutrone, F Broccatelli; <i>Balanced Permeability Index: a multi-parameter index for improved in-vitro permeability, </i>ACS Medicinal Chemistry Letters 15 (4) 457 462 (2024)</p> <p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri'><span style='mso-list:Ignore'>8.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><![endif]><span dir=LTR></span>S Hollingsworth, et al, DR Weiss, V Shanmugasundaram; <i>The Rise of Targeting Chimeras (TACs): Next-Generation Medicines that Preempt Cellular Events</i>, Medicinal Chemistry Research 32, 1294 1314 (2023)</p> <p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri'><span style='mso-list:Ignore'>9.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><![endif]><span dir=LTR></span><b>DR Weiss</b>, A Bortolato,Y Sun,X Cai, C Lai, S Guo, L Shi, V<span style='mso-spacerun:yes'>  </span>Shanmugasundaram; <i>On Ternary Complex Stability in Protein Degradation: In-silico molecular glue binding affinity calculations</i> <span style='color:black'>Journal of Chemical Information and Modeling, 63 (8) 2382 2392 </span>(2023)<i> </i></p> <p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri'><span style='mso-list:Ignore'>10.<span style='font:7.0pt "Times New Roman"'>&nbsp; </span></span></span><![endif]><span dir=LTR></span><b><span style='color:black'>DR Weiss</span></b><span style='color:black'>, J Karpiak, XP Huang, MF Sassanno, J Lyu, BL Roth, BK Shoichet; <i>Selectivity Challenges in Docking Screens for GPCR Targets and Antitargets</i> Journal of Medicinal Chemistry 61 (15), 6830-6845 (2018)</span></p> <p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri'><span style='mso-list:Ignore'>11.<span style='font:7.0pt "Times New Roman"'>&nbsp; </span></span></span><![endif]><span dir=LTR></span><span style='color:black'>M Korczynska, MJ Clark, C Valant, J Xu, E Von Moo, S Albold, DR Weiss, et al, RK Sunahara; <i>Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor</i> Proceedings of the National Academy of Sciences 115 (10) E2419-E2428 (2018)</span></p> <p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri'><span style='mso-list:Ignore'>12.<span style='font:7.0pt "Times New Roman"'>&nbsp; </span></span></span><![endif]><span dir=LTR></span><b><span style='color:black'>DR Weiss</span></b><span style='color:black'>, A Bortolato, B Tehan, JS Mason; <i>GPCR-Bench: A Benchmarking Set and Practitioners Guide for G Protein-Coupled Receptor Docking</i> Journal of Chemical Information and Modeling 56 (4),642-651 (2016)</span></p> <p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri'><span style='mso-list:Ignore'>13.<span style='font:7.0pt "Times New Roman"'>&nbsp; </span></span></span><![endif]><span dir=LTR></span><span style='color:black'>A Bortolato, F Deflorian, DR Weiss, JS Mason; <i>Decoding the Role of Water Dynamics in Ligand Protein Unbinding: CRF1R as a Test Case</i> Journal of Chemical Information and Modeling 55 (9), 1857-1866 (2015)</span></p> <p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri'><span style='mso-list:Ignore'>14.<span style='font:7.0pt "Times New Roman"'>&nbsp; </span></span></span><![endif]><span dir=LTR></span><span style='color:black'>KA Bennet, AS Doré, JA Christopher, DR Weiss, FH Marshall; <i>Structures of mGluRs shed light on the challenges of drug development of allosteric modulators</i> Current Opinion in Pharmacology 20:1 7 (2015)</span></p> <p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri'><span style='mso-list:Ignore'>15.<span style='font:7.0pt "Times New Roman"'>&nbsp; </span></span></span><![endif]><span dir=LTR></span><span style='color:black'>DA Silva, DR Weiss, FD Avila; LT Da, M Levitt, D Wang; X Huang; <i>Millisecond dynamics of RNA polymerase II translocation at atomic resolution </i>Proceedings of the National Academy of Sciences 111 (21) : 7665-7670 (2014)</span></p> <p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri'><span style='mso-list:Ignore'>16.<span style='font:7.0pt "Times New Roman"'>&nbsp; </span></span></span><![endif]><span dir=LTR></span><b><span style='color:black'>DR Weiss,</span></b><span style='color:black'> P Koehl;&nbsp;<i>Morphing Methods to Visualize Coarse-Grained Protein Dynamics </i>Protein Dynamics : 271-282 (2014)</span></p> <p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri'><span style='mso-list:Ignore'>17.<span style='font:7.0pt "Times New Roman"'>&nbsp; </span></span></span><![endif]><span dir=LTR></span><span style='color:black'>RG Coleman, TS Sterling, DR Weiss;&nbsp;<i>SAMPL4 &amp; DOCK3. 7: lessons for automated docking procedures </i>Journal of Computer-Aided Molecular Design : 41883 (2014)</span></p> <p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri'><span style='mso-list:Ignore'>18.<span style='font:7.0pt "Times New Roman"'>&nbsp; </span></span></span><![endif]><span dir=LTR></span><b><span style='color:black'>DR Weiss</span></b><span style='color:black'>*, SK Ahn*, MF Sassano, A Kleist, X Zhu, R Strachan, BL Roth, RJ Lefkowitz, BK Shoichet;&nbsp;<i>Conformation Guides Molecular Efficacy in Docking Screens of Activated ²-2 Adrenergic G Protein Coupled Receptor </i>ACS chemical biology (8) : 1018-1026 (2013)&nbsp;&nbsp;&nbsp; </span></p> <p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri'><span style='mso-list:Ignore'>19.<span style='font:7.0pt "Times New Roman"'>&nbsp; </span></span></span><![endif]><span dir=LTR></span><span style='color:black'>AC Kruse*, <b>DR Weiss*</b>, M Rossi, J Hu, K Hu, K Eitel, P Gmeiner, J Wess, BK Kobilka, BK Shoichet;&nbsp;<i>Muscarinic Receptors as Model Targets and Antitargets for Structure-Based Ligand Discovery </i>Molecular pharmacology (84) : 528-540 (2013)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></p> <p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri'><span style='mso-list:Ignore'>20.<span style='font:7.0pt "Times New Roman"'>&nbsp; </span></span></span><![endif]><span dir=LTR></span><span style='color:black'>JS Mason*, A Bortolato*, <b>DR Weiss</b>*, F Deflorian, B Tehan, FH Marshall;&nbsp;<i>High end GPCR design: crafted ligand design and druggability analysis using protein structure, lipophilic hotspots and explicit water networks </i>In Silico Pharmacology (1) : 23 (2013)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></p> <p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri'><span style='mso-list:Ignore'>21.<span style='font:7.0pt "Times New Roman"'>&nbsp; </span></span></span><![endif]><span dir=LTR></span><span style='color:black'>MM Mysinger*, <b>DR</b> <b>Weiss</b>*, JJ Ziarek*, S Gravel; AK Doak, J Karpiak, N Heveker, BK Shoichet, BF Volkman;&nbsp;<i>Structure-based ligand discovery for the protein protein interface of chemokine receptor CXCR4 </i>Proceedings of the National Academy of Sciences (109) : 5517-5522 (2012)&nbsp;&nbsp;&nbsp; </span></p> <p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri'><span style='mso-list:Ignore'>22.<span style='font:7.0pt "Times New Roman"'>&nbsp; </span></span></span><![endif]><span dir=LTR></span><span style='color:black'>JK Bray, DR Weiss, M Levitt;&nbsp;<i>Optimized Torsion-Angle Normal Modes Reproduce Conformational Changes More Accurately Than Cartesian Modes </i>Biophysical journal (101) : 2966 (2011)</span></p> <p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri'><span style='mso-list:Ignore'>23.<span style='font:7.0pt "Times New Roman"'>&nbsp; </span></span></span><![endif]><span dir=LTR></span><span style='color:black'>X Huang, D Wang, DR Weiss, DA Bushnell, RD Kornberg, M Levitt;&nbsp; <i>RNA polymerase II trigger loop residues stabilize and position the incoming nucleotide triphosphate in transcription </i>Proceedings of the National Academy of Sciences (107) : 15745-15750 (2010)</span></p> <p class=MsoListParagraph style='text-indent:-.25in;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri'><span style='mso-list:Ignore'>24.<span style='font:7.0pt "Times New Roman"'>&nbsp; </span></span></span><![endif]><span dir=LTR></span><b><span style='color:black'>DR Weiss</span></b><span style='color:black'>, M Levitt;&nbsp;<i>Can morphing methods predict intermediate structures? </i>Journal of molecular biology (385) : 665-674 (2009)</span></p> <p class=MsoListParagraph style='margin-top:6.0pt;text-indent:-.25in; line-height:12.0pt;mso-list:l0 level1 lfo2'><![if !supportLists]><span style='mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri; color:black'><span style='mso-list:Ignore'>25.<span style='font:7.0pt "Times New Roman"'>&nbsp; </span></span></span><![endif]><span dir=LTR></span><b><span style='color:black'>DR Weiss</span></b><span style='color:black'>, TM Raschke, M Levitt;&nbsp; <i>How hydrophobic buckminsterfullerene affects surrounding water structure </i>The Journal of Physical Chemistry B (112) : 2981-2990 (2008)<o:p></o:p></span></p> <p class=MsoListParagraph style='margin-top:6.0pt;line-height:12.0pt'><span style='color:black'>*equal contributors<o:p></o:p></span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:12;mso-row-margin-right:234.2pt'> <td width=402 colspan=2 valign=top style='width:301.7pt;border:none; border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt'><span style='font-size:12.0pt;font-family:"Times",serif;mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:EN-US; mso-bidi-language:AR-SA'><br clear=all style='page-break-before:always'> </span> <p class=MsoNormal style='line-height:12.0pt'><b><span style='color:navy; text-transform:uppercase'>PAST Research Positions</span></b></p> </td> <td width=332 colspan=6 valign=top style='width:249.1pt;border:none; border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'>&nbsp;</p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:13'> <td width=734 colspan=8 valign=top style='width:7.65in;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>Associate Director, Molecular Structure and Design<span style='mso-spacerun:yes'>                                                        </span><span style='mso-spacerun:yes'>                                              </span>2023-2024<o:p></o:p></span></p> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>Senior Principal Scientist, Molecular Structure and Design<span style='mso-spacerun:yes'>                                                                                           </span>2020-2023<o:p></o:p></span></p> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>Bristol-Myers-Squibb, Redwood City, CA<span style='mso-spacerun:yes'>                                                                                                          </span></span></p> </td> <td width=156 colspan=2 valign=top style='width:117.1pt;padding:0in 0in 0in 0in'> <p class=MsoNormal><o:p>&nbsp;</o:p></p> </td> <td width=156 valign=top style='width:117.1pt;padding:0in 0in 0in 0in'></td> </tr> <tr style='mso-yfti-irow:14;mso-row-margin-right:234.2pt'> <td width=734 colspan=8 valign=top style='width:7.65in;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:black'>In this role, I championed a predictive mindset, emphasizing Structure Based Design and the utilization of predictive Machine Learning models to guide all synthetic decisions throughout the design-make-test-analyze cycle. I demonstrated meaningful difference in the progression of new chemical matter for the benefit of patients. I recruited, trained, and led a group of three computational scientists at the Redwood City site. Additionally, I formed and guided a matrix organization devoted to advancing predictive modelling in targeted protein degradation, and in that capacity, initiated an academic collaboration to study ternary complex prediction. <o:p></o:p></span></p> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:black'><o:p>&nbsp;</o:p></span></p> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>Senior Scientist, Modelling group leader, Nurix Inc, San Francisco, USA&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2015-2020</span><span style='font-size:10.0pt;font-family:"Times New Roman",serif;color:black'><o:p></o:p></span></p> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:black'>E2 conjugating enzymes and E3 ligases control protein stability and protein fate through the Ubiquitin Proteasome System (UPS). Small molecule enhancers and inhibitors of E2 and E3 enzymes provide an innovative path to regulate key actors in cell fate through modulation of the UPS. I am leading the predictive design of bifunctional molecules for targeted protein degradation, applying protein-protein docking and prediction of ternary complex formation, and advanced ADME prediction for Beyond Ro5 space.<o:p></o:p></span></p> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:black'><o:p>&nbsp;</o:p></span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:15;mso-row-margin-right:234.2pt'> <td width=734 colspan=8 valign=top style='width:7.65in;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='margin-top:6.0pt;line-height:12.0pt'><span style='font-size:10.0pt;font-family:"Times New Roman",serif;color:navy'>Senior Scientist, Computer Aided Drug Design, Heptares Therapeutics Limited, UK&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2013-2015<br> </span><span style='font-size:10.0pt;font-family:"Times New Roman",serif; color:black;mso-themecolor:text1'>G-protein coupled receptors (GPCRs), are the largest superfamily of proteins in the human body and are the targets of &gt;30% of all marketed drugs.&nbsp;At Heptares Therapeutics, I applied computer aided drug design to challenging GPCR targets as part of the drug discovery team. I led the development of new computational methods for use of water structure in docking and lead optimization, MD simulation, Free Energy Perturbation in GPCRs and prediction of drug binding kinetics.<o:p></o:p></span></p> <p class=MsoNormal style='margin-top:6.0pt;line-height:12.0pt'><span style='font-size:10.0pt;font-family:"Times New Roman",serif;color:navy'>Post-doctoral research, Shoichet lab, Pharmaceutical Chemistry, University of California, San Francisco, USA<span style='mso-spacerun:yes'>                  </span>2009-2013<o:p></o:p></span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:16;mso-row-margin-right:234.2pt'> <td width=734 colspan=8 valign=top style='width:7.65in;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:black'>I applied virtual screening and GPCR homology modeling for the discovery of new chemical matter for GPCR targets, including the rational design of selectivity for receptor subtypes and ligand efficacy.</span></p> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:black'>&nbsp;</span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:17;mso-row-margin-right:234.2pt'> <td width=734 colspan=8 valign=top style='width:7.65in;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>Visiting scholar, INRIA, French National Institute for Research in Computer Science and Control,&nbsp; France<span style='mso-spacerun:yes'>                         </span>2008</span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:18;mso-row-margin-right:234.2pt'> <td width=734 colspan=8 valign=top style='width:7.65in;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><i><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:black'>Geometries of waters at protein-protein interfaces in the dynamic setting</span></i></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:19;mso-row-margin-right:234.2pt'> <td width=734 colspan=8 valign=top style='width:7.65in;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:black'>I applied computational geometry techniques to study the interaction and dynamics of water in the protein-protein interface.</span></p> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:black'>&nbsp;</span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:20;mso-row-margin-right:234.2pt'> <td width=734 colspan=8 valign=top style='width:7.65in;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>Ph.D. Studies, Levitt Lab, Department of Chemistry, Stanford University, USA<span style='mso-spacerun:yes'>                                                                    </span>2003-2009</span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:21;mso-row-margin-right:234.2pt'> <td width=734 colspan=8 valign=top style='width:7.65in;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><i><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:black'>Coarse graining of protein dynamics</span></i></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:22;mso-row-margin-right:234.2pt'> <td width=734 colspan=8 valign=top style='width:7.65in;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:black'>Protein dynamics important to biological function often happen on a time scale that is unattainable through detailed simulation methods such as molecular dynamics (MD). We developed a novel interpolation method to study transitions between known crystal structures that does not extrapolate motion linearly and can therefore move around high energy barriers. The interpolation method I developed was used in several methods as a starting point for long-time-scale simulation.<o:p></o:p></span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:23;mso-row-margin-right:234.2pt'> <td width=734 colspan=8 valign=top style='width:7.65in;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><i><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:black'>Simulated behavior of nanoscale hydrophobic solutes in water </span></i></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:24;mso-row-margin-right:234.2pt'> <td width=734 colspan=8 valign=top style='width:7.65in;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:black'>Using MD simulation, we studied details of the water structure surrounding a single molecule of Buckminsterfullerene (C<sub>60</sub>). We showed ordering of water in both the first and second hydration shell, and an increase of hydrogen bonding within shells, with important implications for nanomaterials.</span></p> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:black'>&nbsp;<o:p></o:p></span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:25;mso-row-margin-right:234.2pt'> <td width=734 colspan=8 valign=top style='width:7.65in;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>M.S. Studies, Department of Biochemistry, Tel Aviv University, Israel<span style='mso-spacerun:yes'>                                                                               </span>2001-2003</span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:26;mso-row-margin-right:234.2pt'> <td width=734 colspan=8 valign=top style='width:7.65in;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><i><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:black'>The Anti-Codon Nuclease active site</span></i></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:27;mso-row-margin-right:234.2pt'> <td width=734 colspan=8 valign=top style='width:7.65in;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:black'>We used multiple sequence alignment and secondary structure predictions to study a t-RNA nuclease with anti-HIV potential. Predicted mutations were experimentally shown to alter cleavage patterns, with possible therapeutic applications.</span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:28;mso-row-margin-right:234.2pt'> <td width=734 colspan=8 valign=top style='width:7.65in;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoBodyTextIndent2 style='margin-left:9.0pt;text-align:justify; line-height:12.0pt;text-autospace:ideograph-other'>&nbsp;</p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:29;mso-row-margin-right:234.2pt'> <td width=734 colspan=8 valign=top style='width:7.65in;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>B.S. Studies, Department of Biotechnology, Tel Aviv University, Israel<span style='mso-spacerun:yes'>                                                                              </span>2000-2001<span style='mso-spacerun:yes'>  </span></span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:30;mso-row-margin-right:234.2pt'> <td width=734 colspan=8 valign=top style='width:7.65in;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><i><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:black'>Kinetics of self-assembly in amyloidal fibrils: Biophysical studies</span></i></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:31;mso-row-margin-right:234.2pt'> <td width=734 colspan=8 valign=top style='width:7.65in;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:black'>We used biophysical measurements (CD and ELISA) to characterize the kinetics of self-assembly in amyloid fibrils.</span></p> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; color:black'>&nbsp;</span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:32;mso-row-margin-right:234.2pt'> <td width=578 colspan=6 valign=top style='width:433.4pt;border-top:solid windowtext 1.0pt; border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none; padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><b><span style='color:navy; text-transform:uppercase'>Awards and Honors</span></b></p> </td> <td width=157 colspan=2 valign=top style='width:117.4pt;border-top:solid windowtext 1.0pt; border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none; padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'>&nbsp;</p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:33;mso-row-margin-right:234.2pt'> <td width=578 colspan=6 valign=top style='width:433.4pt;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='margin-top:6.0pt;line-height:12.0pt'><span style='font-size:10.0pt;font-family:"Times New Roman",serif;color:navy'>NIH NRSA for Individual Postdoctoral Fellows, F32 GM093580-01, UCSF&nbsp;</span></p> </td> <td width=157 colspan=2 valign=top style='width:117.4pt;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='margin-top:6.0pt;margin-right:0in;margin-bottom: 6.0pt;margin-left:0in;line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>2009-2012</span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:34;mso-row-margin-right:234.2pt'> <td width=578 colspan=6 valign=top style='width:433.4pt;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>SimBios, NIH Center for Biomedical Computation, Full fellowship, Stanford</span><span style='font-size:10.0pt;font-family:"Times New Roman",serif;color:black'><br> </span><span style='font-size:10.0pt;font-family:"Times New Roman",serif'>SimBios is an NIH funded center, awarding up to 3 full doctoral fellowships each year. </span></p> <p class=MsoNormal style='margin-left:9.0pt;line-height:12.0pt'><span style='font-size:10.0pt;font-family:"Times New Roman",serif;color:navy'>&nbsp;</span></p> </td> <td width=157 colspan=2 valign=top style='width:117.4pt;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>2007-2009</span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:35;mso-row-margin-right:234.2pt'> <td width=578 colspan=6 valign=top style='width:433.4pt;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>Program in Mathematics and Molecular Biology, Full fellowship, Stanford<br style='mso-special-character: line-break'> <![if !supportLineBreakNewLine]><br style='mso-special-character:line-break'> <![endif]></span></p> </td> <td width=157 colspan=2 valign=top style='width:117.4pt;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>2006-2007</span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:36;mso-row-margin-right:234.2pt'> <td width=578 colspan=6 valign=top style='width:433.4pt;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='margin-bottom:12.0pt;line-height:12.0pt'><span style='font-size:10.0pt;font-family:"Times New Roman",serif;color:navy'>Wise Scholarship for Masters Studies, Full fellowship, Tel Aviv University</span><span style='font-size:10.0pt;font-family:"Times New Roman",serif;color:#333333'> </span></p> </td> <td width=157 colspan=2 valign=top style='width:117.4pt;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>2001-2003</span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:37;mso-row-margin-right:234.2pt'> <td width=578 colspan=6 valign=top style='width:433.4pt;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><i><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>Magna cum laude</span></i><span style='font-size:10.0pt;font-family:"Times New Roman",serif;color:navy'>, B.S. Studies, Chemistry and Biology </span></p> <p class=MsoNormal style='margin-left:.25in;line-height:12.0pt'><span style='font-size:10.0pt;font-family:"Times New Roman",serif;color:navy'>&nbsp;</span></p> </td> <td width=157 colspan=2 valign=top style='width:117.4pt;padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>2001</span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:38;mso-row-margin-right:234.2pt'> <td width=734 colspan=8 valign=top style='width:7.65in;border-top:solid windowtext 1.0pt; border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none; padding:0in 5.4pt 0in 5.4pt'> <p class=MsoNormal style='line-height:12.0pt'><b><span style='color:navy; text-transform:uppercase'>talks and workshops (Selection)</span></b></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:39;height:15.3pt;mso-row-margin-right:234.2pt'> <td width=578 colspan=6 valign=top style='width:433.4pt;padding:0in 5.4pt 0in 5.4pt; height:15.3pt'> <p class=MsoNormal style='margin-bottom:6.0pt;line-height:12.0pt'><span style='font-size:10.0pt;font-family:"Times New Roman",serif;color:black'>Gordon Research Conference Computer Aided Drug Design, Mount Snow, Vermont, USA  &quot;Cereblon dynamics, ternary complex stability and CELMoD optimization&quot;<o:p></o:p></span></p> <p class=MsoNormal style='margin-bottom:6.0pt;line-height:12.0pt'><span style='font-size:10.0pt;font-family:"Times New Roman",serif;color:black'>American Chemical Society National Meeting, Chicago, USA  Structure based drug design for prediction of molecular glue degradation potency <o:p></o:p></span></p> </td> <td width=157 colspan=2 valign=top style='width:117.4pt;padding:0in 5.4pt 0in 5.4pt; height:15.3pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>July 2023<o:p></o:p></span></p> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'><o:p>&nbsp;</o:p></span></p> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>August 2022<o:p></o:p></span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:40;height:15.3pt;mso-row-margin-right:234.2pt'> <td width=578 colspan=6 valign=top style='width:433.4pt;padding:0in 5.4pt 0in 5.4pt; height:15.3pt'> <p class=MsoNormal style='margin-bottom:6.0pt;line-height:12.0pt'><span style='font-size:10.0pt;font-family:"Times New Roman",serif;color:black'>American Chemical Society National Meeting, San Diego, USA  Computational Modelling Workflow to Characterize the Structure of Bi-functional Degrader-Protein-Protein Ternary Complex <o:p></o:p></span></p> </td> <td width=157 colspan=2 valign=top style='width:117.4pt;padding:0in 5.4pt 0in 5.4pt; height:15.3pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>August 2019<o:p></o:p></span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <tr style='mso-yfti-irow:41;mso-yfti-lastrow:yes;height:15.3pt;mso-row-margin-right: 234.2pt'> <td width=578 colspan=6 valign=top style='width:433.4pt;padding:0in 5.4pt 0in 5.4pt; height:15.3pt'> <p class=MsoNormal style='margin-bottom:6.0pt;line-height:12.0pt'><a name="OLE_LINK3"><span style='font-size:10.0pt;font-family:"Times New Roman",serif; color:black'>American Chemical Society National Meeting, </span></a><span style='font-size:10.0pt;font-family:"Times New Roman",serif;color:black'>San Francisco, USA  GPCR drug-binding kinetics: Insights from explicit water network modeling </span></p> </td> <td width=157 colspan=2 valign=top style='width:117.4pt;padding:0in 5.4pt 0in 5.4pt; height:15.3pt'> <p class=MsoNormal style='line-height:12.0pt'><span style='font-size:10.0pt; font-family:"Times New Roman",serif;color:navy'>August 2014</span></p> </td> <td style='mso-cell-special:placeholder;border:none;padding:0in 0in 0in 0in' width=312 colspan=3><p class='MsoNormal'>&nbsp;</td> </tr> <![if !supportMisalignedColumns]> <tr height=0> <td width=191 style='border:none'></td> <td width=211 style='border:none'></td> <td width=15 style='border:none'></td> <td width=50 style='border:none'></td> <td width=94 style='border:none'></td> <td width=16 style='border:none'></td> <td width=2 style='border:none'></td> <td width=155 style='border:none'></td> <td width=1 style='border:none'></td> <td width=155 style='border:none'></td> <td width=156 style='border:none'></td> </tr> <![endif]> </table> <p class=MsoNormal style='line-height:12.0pt'><o:p>&nbsp;</o:p></p> </div> </body> </html>